Antimicrobial Effectiveness Testing

Pharmaceutical and cosmetic preparations often require antimicrobial activity to prevent microbial proliferation or to limit the effects of contamination. The Pharmacopoeias require testing these products for the efficacy of antimicrobial preservation (e.g. USP 51, EP 5.1.3, JP19). Preparing consistent inocula for these tests can be laborious and is often unreliable, necessitating time consuming repeat assays.

BioBall MultiShot 10E8 is ideal for this application and simplifies preparation and provides a precise inoculum.

Designed to provide 10 precise inoculations over a 2 hour period

  • Each BioBall MultiShot 10E8 has a batch mean between 0.7 and 1.5 x 108 cfu
  • Standard deviation is less than or equal to 20% of the batch mean
  • When re-hydrated with 1.1 mL of re-hydration fluid it provides 10 x 100μL doses of 107 cfu
  • 2 hour stability when re-hydrated with BioBall Re-Hydration Fluid and stored between 2ºC to 8ºC.
  • Each 100 μL aliquot can be used to inoculate for example 20 mL of product, resulting in the required final concentration of 105 – 106 cfu/mL product

BioBall Advantages

Over controls prepared by serial dilution:

  • Little or no preparation time
  • Easy to use
  • Precise known number of cfu
  • Consistent number of cfu batch to batch

Over other multi dose products:

  • Far less preparation time and steps
  • Greater precision
  • Consistent number of cfu batch to batch
  • Reduces risk of "Failed QC" due to variability of the control

The video below demonstrates how to use BioBall MultiShot 10E8 for Antimicrobial Effectiveness Testing 

Viewing time 1:26min  

For more information click on "Product Notes" on the left hand side navigation bar and download the BioBall Pharmaceutical Sales Flyers.